RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor
cells. Combining chemotherapy with radiation therapy may kill more tumor cells.
PURPOSE: Phase I trial to study the effectiveness of doxorubicin plus external-beam
radiation therapy in treating patients who have soft tissue sarcoma.
OBJECTIVES: I. Determine the toxicity and maximum tolerated dose of doxorubicin when
combined with external beam radiotherapy in patients with high risk soft tissue sarcomas of
the extremity or trunk. II. Assess the radiographic and pathologic response rates to this
preoperative regimen in the subset of these patients with measurable disease.
OUTLINE: This is a dose escalation study of doxorubicin. Patients receive doxorubicin
intravenous (IV) bolus followed immediately by doxorubicin IV over 4 days every week for 5
weeks in the absence of unacceptable toxicity. Patients with measurable disease receive
external beam radiotherapy 5 days a week for 5 weeks concurrently with doxorubicin
treatment. Patients with measurable disease undergo surgical resection of the residual mass
4-7 weeks following completion of chemoradiation. Patients who have no measurable disease
and have undergone prereferral excision undergo surgical resection of the prior surgical
scar and tumor bed followed by external beam radiotherapy 5 days a week for 5 weeks. Cohorts
of 3 patients receive escalating doses of doxorubicin until the maximum tolerated dose (MTD)
is determined. Patients are followed every 3 months for 3 years, every 4 months for 2 years,
and then annually for 5 years.
PROJECTED ACCRUAL: A maximum of 30 patients will be accrued for this study at a rate of 5-6
patients per month.
1. Patients must have cytologic or histologic proof of large (>5 mc), Grade III,
resectable soft tissue sarcoma of the extremity or trunk (AJCC Stage IIIB). Patients
with The American Joint Committee on Cancer (AJCC) Stage IIB tumors (Grade II)
greater than 8 cms will also be eligible.
2. Patients may have measurable or non-measurable disease (C/P pre-referral excision).
3. Patients may have had prior doxorubicin (up to a total doxorubicin dose of 450
4. Patients may have a prior history of malignancy (at the discretion of the Principal
5. Patients must have Karnofsky Point Scale (P.S.)> of >70 or Xubrod P.S. of 0 or 1.
6. Patients must have: Absolute neutrophil count (ANC) > 1,500 cells/mm; platelet count
> 100,000 platelets/ml; serum creatinine <1.8 mg/dl, aspartate aminotransferase (AST
or SGOT) and alanine aminotransferase (ALT or SGPT) < 3 times normal, total bilirubin
< 1.5mg/dl; for patients with cumulative Adriamycin 450 mg/M2, EF >50%.
7. Women of childbearing potential must not be pregnant or breast feeding and must
practice adequate contraception.
1. Patients must not have had prior radiation therapy (XRT) in the area of the primary
tumor, and the anticipated XRT field must not include the perineum, scrotum, or
2. Patients with uncontrolled coexisting medical conditions are excluded.
3. Patient must not be pregnant or brest feeding.