Phase I trial to study the effectiveness of a tumor cell vaccine and interferon gamma in
patients with refractory epithelial ovarian cancer. Vaccines made from a person's cancer
cells may make the body build an immune response to and kill their tumor cells. Combining
vaccine therapy with interferon gamma may be a more effective treatment for epithelial
I. Determine whether intraperitoneal (IP) injections of epithelial ovarian carcinoma cells
infected with ALVAC-hB7.1 and IP interferon gamma have acceptable toxicity and produce any
clinical responses in patients with refractory ovarian epithelial cancer.
OUTLINE: This is a dose-escalation study of ALVAC-hB7.1 infected tumor cells.
Patients receive ALVAC-hB7.1 infected tumor cells intraperitoneally (IP) on days 4, 11, and
18. Patients also receive interferon gamma IP on days 8, 10, 15, and 17. In the absence of
disease progression, up to 6 courses of therapy may be given. If insufficient tumor cells
are available to continue treatment with tumor cell derived vaccine, interferon gamma may be
given alone. Cohorts of 3 to 6 patients receive escalating doses of ALVAC-hB7.1 infected
tumor cells until the maximum tolerated dose (MTD) is determined. The MTD is defined as the
dose at which no more than 2 of 6 patients experience dose-limiting toxicity.
Patients are followed every 6 months until disease progression.
PROJECTED ACCRUAL: A total of 12 patients will be accrued for this study.
- Diagnosis of ovarian epithelial carcinoma
- Previously treated with an adequate course of platinum based chemotherapy
- Evidence of intraabdominal disease
- No significant adhesions
- Performance status - Zubrod 0-2
- Lymphocyte count at least 500/mm^3
- Bilirubin no greater than 1.5 mg/dL
- SGOT less than 2.5 times upper limit of normal
- Creatinine no greater than 1.5 mg/dL
- No major disorder of the cardiovascular system
- No major disorder of the pulmonary system
- Not pregnant or nursing
- Fertile patients must use effective contraception
- Successful placement of peritoneal catheter
- No overt autoimmune disease
- No concurrent chronic steroid therapy
- No prior radiotherapy
- Prior surgery allowed
- Recovered from prior therapy