RATIONALE: Genetic studies may help in understanding the genetic processes that cause some
types of cancer.
PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III
- Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients
with colon cancer.
- Determine if patient prognosis is dependent on the region of 8p AI.
- Perform fine mapping studies to further localize the putative tumor suppressor gene(s)
- Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the
prognosis of patients whose tumors exhibit 8p AI.
OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8
markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136
at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping
- Diagnosis of resectable stage II or III adenocarcinoma of the colon
- Participated in NCCTG-914653
- DNA extracted from both normal and tumor tissue
- Under 70