Expired Study
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Denver, Colorado 80217


Purpose:

Phase II trial to study the effectiveness of broxuridine in treating patients who are undergoing surgery for stage I or stage II prostate cancer. Broxuridine may help doctors determine the rate of growth of prostate tumors and help them plan effective treatment


Study summary:

OBJECTIVES: I. Measure the potential doubling times of multifocal adenocarcinomas of the prostate using broxuridine. II. Determine whether the doubling times of multifocal carcinomas occurring within a single prostate are consistent with a model in which low-volume carcinomas have slow doubling times and high-volume carcinomas have fast doubling times. OUTLINE: Patients receive broxuridine IV over 30 minutes on day -1. Approximately 12-96 hours later, patients undergo surgery to remove the prostate. Tumor tissue is examined by immunostaining for the presence of broxuridine to determine doubling times of the tumor.


Criteria:

Inclusion Criteria: - Diagnosis of stage I or II (T1-2) carcinoma of the prostate - PSA greater than 8 ng/mL - Abnormal findings on digital rectal examination - Eligible for radical prostatectomy - Performance status - ECOG 0 or 1 - No prior biologic therapy - No prior chemotherapy - No prior neoadjuvant hormonal therapy - No prior radiotherapy - See Disease Characteristics - No prior therapy that would affect tumor growth rates or volume


NCT ID:

NCT00003832


Primary Contact:

Principal Investigator
Leonard Glode
University of Colorado, Denver


Backup Contact:

N/A


Location Contact:

Denver, Colorado 80217
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 22, 2017

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