RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase I trial to study the effectiveness of bryostatin 1 plus cisplatin in treating
patients who have metastatic or unresectable cancer.
OBJECTIVES: I. Determine the maximum tolerated dose and dose limiting toxicity of bryostatin
1 in combination with cisplatin in patients with advanced malignancy. II. Determine the
recommended phase II doses of bryostatin 1 and cisplatin in both a 21 day and 14 day course,
based on toxicity, effect on protein kinase C activity, and pharmacokinetics, in this
patient population. III. Determine the pharmacokinetics of bryostatin 1 in these patients.
IV. Identify any objective tumor responses arising from treatment in these patients.
OUTLINE: This is a dose escalation study of bryostatin 1. Cohorts 1-7: Patients receive
cisplatin IV over 1 hour on day 1 of the first course. Subsequent courses repeat every 21
days with bryostatin 1 IV over 24 hours on day 1 and cisplatin IV over 1 hour on day 2 in
the absence of disease progression or unacceptable toxicity. Cohorts 8-10: Patients receive
cisplatin as in cohorts 1-7. Subsequent courses repeat every 21 days with bryostatin 1 IV
over 1 hour followed by cisplatin on day 1. Cohort 11: Patients receive bryostatin 1 and
cisplatin as in cohorts 8-10. Cohorts of 3-6 patients receive escalating doses of bryostatin
1 or cisplatin until the maximum tolerated dose (MTD) of is determined. The MTD is defined
as the dose preceding that at which 2 of 3 or 2 of 6 patients experience DLT. The
recommended phase II dose (RPTD) is defined as the dose preceding the MTD. After the RPTD is
determined for the 21 day schedule, cohorts of patients receive escalating doses of
bryostatin and constant doses of cisplatin on a 14 day schedule. The MTD14 and RPTD14 are
determined in the same manner as above. Patients are followed for 6 months.
PROJECTED ACCRUAL: A total of 36-72 patients will be accrued for this study.
DISEASE CHARACTERISTICS: Histologically confirmed metastatic or unresectable malignant
disease Prior brain metastases with no residual signs or symptoms or medications allowed
PATIENT CHARACTERISTICS: Age: Over 18 Performance status: ECOG 0-2 Life expectancy: At
least 3 months Hematopoietic: Granulocyte count at least 1,500/mm3 Platelet count at least
100,000/mm3 Hepatic: Bilirubin less than 1.5 times upper limit of normal (ULN) AST/ALT no
greater than 2.5 times ULN Alkaline phosphatase no greater than 2.5 times ULN Renal:
Creatinine no greater than 1.5 mg/dL Other: Not pregnant or nursing Fertile patients must
use effective contraception No concurrent condition that would preclude study No
psychological, familial, sociological, or geographical condition that might compromise
medical follow up No neuropathy greater than grade 1, including hearing loss
PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: At least 3 weeks
since prior chemotherapy (6 weeks for mitomycin or nitrosoureas)and recovered Prior
cisplatin allowed Endocrine therapy: Not specified Radiotherapy: At least 2 weeks since
prior radiotherapy Prior radiotherapy for brain metastases allowed Surgery: Not specified