Expired Study
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Laguna Hills, California 92656


Purpose:

The objectives of this study are to determine the effects of isoprinosine in patients diagnosed as having unexplained generalized lymphadenopathy. Variables to be examined will include: Signs and symptoms: - Lymphadenopathy. - Fever. - Weight loss. - Occurrence of opportunistic infections. Cell-mediated immune system parameters: - T-helper cell (OKT4) numbers and proportions. - T-suppressor cell (OKT8) numbers and proportions. - Natural killer (NK) cell activity. - Lymphocyte blastogenic response to phytohemagglutinin (PHA). - Lymphocyte blastogenic response to pokeweed mitogen (PWM). - Immunoglobulin (IgG, IgA, IgM, IgE, IgD) profile. - Circulating immune complexes. Infections characteristically associated with AIDS, such as Candida albicans, Pneumocystis carinii pneumonia, Cytomegalovirus, Herpes simplex, Cryptococcus, Histoplasma, Toxoplasma, Cryptosporidium, Mycobacterium avium- intracellulare, Legionella, and Isospora. Safety parameters: - Blood chemistry including serum uric acid (PurposeA-12). - Complete blood count (CBC). - Platelet count.


Criteria:

Exclusion Criteria Co-existing Condition: Patients with a history of gout, uric acid urolithiasis, uric acid nephrolithiasis, renal dysfunction, or gastric ulceration are excluded. Concurrent Medication: Excluded: - Systemic corticosteroids. - Cytotoxic immunosuppressive agents. - Radiotherapy. Critically ill patients or those with CDC-defined AIDS are excluded. Prior Medication: Excluded within 1 month of study entry: - Immunotherapy. Patients with persistent generalized lymphadenopathy (PGL).


NCT ID:

NCT00002297


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

Laguna Hills, California 92656
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 24, 2017

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