The objectives of this study are to determine the effects of isoprinosine in patients
diagnosed as having unexplained generalized lymphadenopathy. Variables to be examined will
Signs and symptoms:
- Weight loss.
- Occurrence of opportunistic infections.
Cell-mediated immune system parameters:
- T-helper cell (OKT4) numbers and proportions.
- T-suppressor cell (OKT8) numbers and proportions.
- Natural killer (NK) cell activity.
- Lymphocyte blastogenic response to phytohemagglutinin (PHA).
- Lymphocyte blastogenic response to pokeweed mitogen (PWM).
- Immunoglobulin (IgG, IgA, IgM, IgE, IgD) profile.
- Circulating immune complexes. Infections characteristically associated with AIDS, such
as Candida albicans, Pneumocystis carinii pneumonia, Cytomegalovirus, Herpes simplex,
Cryptococcus, Histoplasma, Toxoplasma, Cryptosporidium, Mycobacterium avium-
intracellulare, Legionella, and Isospora.
- Blood chemistry including serum uric acid (PurposeA-12).
- Complete blood count (CBC).
- Platelet count.
Patients with a history of gout, uric acid urolithiasis, uric acid nephrolithiasis, renal
dysfunction, or gastric ulceration are excluded.
- Systemic corticosteroids.
- Cytotoxic immunosuppressive agents.
Critically ill patients or those with CDC-defined AIDS are excluded.
Excluded within 1 month of study entry:
Patients with persistent generalized lymphadenopathy (PGL).