Expired Study
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San Francisco, California 94110


Purpose:

To evaluate tolerance, toxicity, and preliminary evidence of antitumor efficacy of intralesionally administered tumor necrosis factor (TNF) and to define a maximum tolerated dose (MTD) for single intralesional injections. In addition, to assess the effects of TNF injections on Kaposi's sarcoma (KS) lesions as measured by P-32 magnetic resonance spectroscopy.


Criteria:

Inclusion Criteria Patients must have: - Biopsy-proven Kaposi's sarcoma (KS) with multiple cutaneous lesions. - Minimum life expectancy of 3 months. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - Clinically significant cardiac disease. - Known hemorrhagic diathesis or active bleeding disorder. - Clinically apparent vascular disease. - Known lipoprotein disorders. - History of seizure disorder or central nervous system (CNS) metastasis. - Additional malignancy. Concurrent Medication: Excluded: - Cardiac agents. - Anticoagulants. - Thrombolytic agents. - Nonsteroidal anti-inflammatory drugs. - Corticosteroids. - Aspirin. - Vasodilators. Patients with the following are excluded: - Additional malignancies or other conditions listed in Patient Exclusion Co-Existing Conditions. Prior Treatment: Excluded within 4 weeks of study entry: - Chemotherapy. - Radiotherapy. - Immunotherapy.


NCT ID:

NCT00002262


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

San Francisco, California 94110
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 24, 2017

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