Expired Study
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Houston, Texas 77074


Purpose:

To evaluate the clinical toxicity, safety, and MTD of WF 10 ( TCDO ) intravenous solution administered to patients with HIV infection. To evaluate the potential anti-HIV activity of TCDO.


Criteria:

Inclusion Criteria Concurrent Medication: Required: - Aerosolized pentamidine (300 mg monthly) as prophylaxis for PCP only in patients with CD4 count <= 200 cells/mm3. Allowed: - PCP prophylaxis with aerosolized pentamidine in patients with CD4 count > 200 cells/mm3, only at the discretion of the treating physician. Patients must have: - HIV positivity. - Absolute CD4 count of 150 - 500 cells/mm3. - At least 6 months of prior zidovudine therapy. - No active opportunistic infection requiring ongoing therapy. - Life expectancy of at least 6 months. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: - Neoplasm other than basal cell carcinoma of the skin. - Clinically significant cardiac disease. - Abnormal neurological status by a standardized assessment including strength, reflex testing, and sensory testing. - Unwilling to comply with protocol requirements. Patients with the following prior conditions are excluded: History of myocardial infarction or arrhythmias. Prior Medication: Excluded within 2 weeks prior to study entry: - Antiretroviral agent or interferon. - Systemic biologic response modifiers, corticosteroids, cytotoxic chemotherapeutic agents, or other drugs that can cause neutropenia or significant nephrotoxicity. - Rifampin or rifampin derivatives. - Systemic anti-infectives. Required: - At least 6 months of prior zidovudine. Active drug or alcohol abuse.


NCT ID:

NCT00002119


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

Houston, Texas 77074
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 19, 2017

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