Expired Study
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San Francisco, California 94109


Purpose:

To assess the safety and tolerance of curdlan sulfate, as well as its anti-HIV activity, in HIV-infected patients with CD4 T-lymphocytes less than 500 cells/mm3, using first single doses and then, after FDA review, daily doses for 7 days.


Study summary:

In Phase I of the study, escalating single doses of intravenous curdlan sulfate are tested. In Phase II, curdlan sulfate is administered daily for 7 days. (NOTE: Phase I is completed.)


Criteria:

Inclusion Criteria Patients must have: - HIV seropositivity. - No current AIDS-defining opportunistic infection, lymphoma, Kaposi's sarcoma, or other malignancy. - CD4 count < 500 cells/mm3. - No critical illness that would shorten life expectancy to < 16 weeks. Exclusion Criteria Concurrent Medication: Excluded: - Antiretroviral or other experimental therapies. - Anticoagulants. - Steroids. - Cytotoxic or immunosuppressive agents. Concurrent Treatment: Excluded: - Radiotherapy. Patients with the following prior condition are excluded: History of heparin sensitivity. Prior Medication: Excluded within 1 month prior to study entry: - Antiretroviral or other experimental therapies. - Anticoagulants. - Steroids. - Cytotoxic or immunosuppressive agents. Prior Treatment: Excluded: - Radiotherapy within 1 month prior to study entry. Active IV drug abuse.


NCT ID:

NCT00002100


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

San Francisco, California 94109
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 19, 2017

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