To assess the efficacy of Saccharomyces boulardii (a nonpathogenic yeast) in producing a
significant reduction in diarrheal symptoms in HIV-infected patients with chronic diarrhea.
- Antiviral medication for HIV infection.
Patients must have:
- Documented HIV infection.
- Chronic diarrhea (for at least 1 month) that is either a manifestation or
complication of documented HIV infection.
- Had a stool culture (Salmonella, Shigella, Campylobacter, and Clostridium difficile)
and stool analysis for ova and parasite (O/P X 3) within the past 2 months.
- Failed antimicrobial treatment for diarrhea OR received no prior antimicrobials for
stool pathogens because stool cultures were negative.
Patients who are on antiviral medications for HIV infection must have received such
medication for at least 2 weeks and must remain on stable dose for weeks 1 and 2 of study.
- Prior antiviral medication for HIV infection (if on such medication, must have
received it for at least 2 weeks).
- Standard antimicrobial therapy for a documented positive gastrointestinal pathogen.
- Gastrointestinal medications that cause diarrhea (e.g., magnesium-containing
- Maintenance antifungal medication for life-threatening fungal infections (other than
fluconazole <= 100 mg/day).