Expired Study
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Laguna Hills, California 92656


Purpose:

The objective of this double-blind placebo-controlled study is to evaluate the effect of Isoprinosine in a group of homogenous male volunteers who present with immunologic defects relative to: - Comparison of total helper and suppressor T-cell number between the groups. - Comparison of the phytohemagglutinins (PHA) and concanavalin A lymphoproliferative response and natural killer (NK) cell activity between the groups. - Determination of the clinical course of the volunteers after discontinuance of Isoprinosine.


Criteria:

Exclusion Criteria Co-existing Condition: Patients with the following are excluded: - Opportunistic infections or Kaposi's sarcoma. - Critical illness. - History of gout, urolithiasis, nephrolithiasis, renal dysfunction, and severe gastric ulcer. Concurrent Medication: Excluded: - Steroids. - Cytotoxic immunosuppressive agents. Concurrent Treatment: Excluded: - Radiotherapy. The following are excluded: - Opportunistic infections or Kaposi's sarcoma. - Critically ill patients. - Patients receiving steroids, cytotoxic immunosuppressive agents, and/or radiotherapy. - Patients who have received any other immunotherapy. - Patients with a history of gout, urolithiasis, nephrolithiasis, renal dysfunction, and severe gastric ulcer. Prior Medication: Excluded: - Any other immunotherapy. Patients who fall into the group which is at risk of developing cutaneous sarcoma and/or opportunistic diseases but at present have no signs or symptoms of these diseases.


NCT ID:

NCT00002059


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

Laguna Hills, California 92656
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 24, 2017

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