Expired Study
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Princeton, New Jersey 08543


Purpose:

To determine the appropriate duration of amphotericin B therapy for Candida esophagitis. To compare the effectiveness of two different amphotericin B doses in the treatment of biopsy-proven Candida esophagitis. To determine if low-dose amphotericin B is less toxic than standard dose therapy during a limited treatment period. To evaluate pharmacokinetic and pharmacodynamic parameters of the two different dosing regimens.


Criteria:

Exclusion Criteria Co-existing Condition: Patients with histological or clinical (skin rash, cotton wool exudates, Candida endophthalmitis, etc.) evidence of disseminated candidiasis are excluded. Concurrent Medication: Excluded: - Systemic administration of amphotericin B for a proven or suspected systemic fungal infection. Patients with the following are excluded: - Documented Candida fungemia. - Histological or clinical (skin rash, cotton wool exudates, Candida endophthalmitis, etc.) evidence of disseminated candidiasis. - Systemic administration of amphotericin B for a proven or suspected systemic fungal infection. - Patient refusal to enter study. Patient must be an immunosuppressed host, with biopsy-proven Candida esophagitis. - Patients with polymicrobial esophagitis will be included as long as Candida esophagitis is documented by esophageal biopsy. - Informed consent must be signed and obtained.


NCT ID:

NCT00002041


Primary Contact:

Principal Investigator
. .
.


Backup Contact:

N/A


Location Contact:

Princeton, New Jersey 08543
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 23, 2017

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