Expired Study
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South San Francisco, California 94080


Purpose:

To determine the safety profile and maximum tolerated dose (MTD) of recombinant soluble human CD4 (rCD4) therapy in patients with AIDS or AIDS related complex (ARC). To obtain a preliminary indication of the antiviral effects of rCD4 in patients with AIDS and ARC. To measure steady state serum levels of rCD4 following continuous infusion therapy.


Criteria:

Inclusion Criteria Patients must have: - HIV-1 seropositivity. - Diagnosis of AIDS or AIDS related complex (ARC). - Failure to tolerate or respond to zidovudine (AZT) or decided to decline AZT therapy. - The ability to sign a written informed consent form prior to treatment. - A willingness to abstain from all other experimental therapy for HIV infection during the entire study period. - A life expectancy of at least 3 months. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - Serious active opportunistic infections. - Malignancies other than Kaposi's sarcoma. Concurrent Medication: Excluded: - Zidovudine (AZT). - Corticosteroids. - Nonsteroidal anti-inflammatory agents (NSAI). - Other experimental therapy. Patients with the following are excluded: - Serious active opportunistic infections. - Malignancies other than Kaposi's sarcoma. Prior Medication: Excluded within 3 weeks of study entry: - Zidovudine (AZT). - Chemotherapy. - Immunomodulators. - Other experimental therapy.


NCT ID:

NCT00002005


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

South San Francisco, California 94080
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: September 19, 2017

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