Kidney diseases related to the immune system include, nephrotic syndrome, glomerulonephritis,
membranous nephropathy, lupus nephritis, and nephritis associated with connective tissue
This study will allow researchers to admit and follow patients suffering from autoimmune
diseases of the kidney. It will attempt to provide information about the causes and specific
abnormalities associated with autoimmune kidney disease.
Patients with kidney disease as a result of their immune system, and patients with diseases
of the immune system who may later develop kidney disease, will be potential subjects for
Patients will undergo a history and physical examination, and standard laboratory test to
more closely understand the causes, signs, symptoms, and responses to medication of these
diseases. Based on these evaluations the patients may qualify as candidates for other
experimental studies. At any time these patients may be asked to submit blood or urine
samples for further research.
Patients with known or suspected immunologically-mediated kidney diseases, including but not
limited to, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis,
and nephritis associated with other systemic or connective tissue disorders, will be
evaluated at the Clinical Center. Patients who have immunologically-mediated diseases with
potential for kidney disease will be evaluated as well. Studies will include characterization
of the clinical and laboratory features of these disorders, studies of natural history and
complications, evaluation of responses to standard treatment, and determination of the
patients' eligibility to enter other experimental diagnostic or therapeutic protocols.
Patients may be asked to contribute blood and/or urine samples for immunological research
- INCLUSION CRITERIA:
Immunologically-mediated renal diseases, proven or suspected.
Immunologically-mediated diseases with potential for kidney disease.
Willingness of the patient or guardian to give informed consent.
Concomitant medical problems which would confound the interpretation of studies of the
immunologic kidney disorder.
Concomitant medical, surgical or other conditions for which inadequate facilities or funds
are available to support their care at the NIH.