Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and
fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid
arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown.
Researchers hope to improve their understanding of the disease process involved in PF and RA
by analyzing specimens collected by bronchoscopy, lung biopsy, lung transplantation, or
autopsy from patients with these conditions.
The purpose of this study is to collect specimens from rheumatoid arthritis patients with
and without pulmonary fibrosis as well as patients with pulmonary fibrosis without
associated diseases or cause (idiopathic pulmonary fibrosis).
The etiology of pulmonary fibrosis in individuals with rheumatoid arthritis is unknown.
Analysis of blood and specimens procured by bronchoscopy, lung biopsy, lung transplantation,
or post-mortem examination from patients with this disorder will contribute to our
understanding of the pathogenetic mechanisms of pulmonary fibrosis in rheumatoid arthritis.
The purpose of this protocol is to obtain blood and specimens by bronchoscopy, lung biopsy,
lung transplantation, or post-mortem examination from rheumatoid arthritis patients with and
without pulmonary fibrosis, individuals with idiopathic pulmonary fibrosis, and healthy
- INCLUSION CRITERIA:
Non-smokers (never smoked or not smoked within the previous 2 years) who are 18 years of
age or older with any of the following:
RA with PF (biopsy-proven), or
Idiopathic PF-only (biopsy-proven), or
Healthy research volunteers by history and indicated tests (individuals without history of
chronic cardiopulmonary disorder, collagen vascular disease, or bleeding disorder) matched
for age (within 5 years) and gender.
Individuals with any of the following:
Forced expiratory volume in one second (FEV(1)) less than 1L.
Inhalational exposure to fibrogenic fibers or dusts (i.e., asbestos, silica, coal,
Chronic cardiopulmonary disorders other than pulmonary fibrosis.
Other collagen vascular disorders (i.e., systemic lupus erythematosus, scleroderma,
polymyositis, mixed connective tissue disease).
Viral infections associated with PF (i.e., hepatitis B, hepatitis C, human
Uncorrectable bleeding diathesis.
Pregnancy or lactation.