Oxaliplatin is an experimental anti-cancer drug that can shrink tumors such as colon cancer.
However, because this drug can damage the kidneys, it is necessary to determine what doses
of the drug can safely be given to patients with poor kidney function.
Patients with advanced cancer, poorly functioning kidneys, and no good standard treatment
options are eligible for this study. Candidates will be screened with imaging tests, such
as CT and MRI scans, to determine the size and location of the cancer and with blood and
urine tests to evaluate kidney and liver function.
Study participants will receive oxaliplatin intravenously (through a vein) every 3 weeks for
as long as the cancer is under control and there are no serious side effects from the drug.
If significant side effects develop, the dosage will be reduced, or the drug will be
stopped. Blood tests to measure blood cell counts will be done at least once a week, and CT
scans, chest X-rays, and MRIs will be done about once every 6 weeks to assess the tumor's
response to the treatment. Additional blood tests will be done at the beginning of the
first two treatment cycles to measure the amount of oxaliplatin in the blood, and urine will
be collected during the first 24 hours of drug treatment to determine how much drug is
eliminated by the body in urine.
Oxaliplatin is a diaminocyclohexane platinum derivative with known anticancer activity in
solid tumors. The recommended single-agent dose of Oxaliplatin in adult cancer patients
with normal renal function is 130 mg/m(2) given intravenously over 2 hours every 3 weeks.
Renal excretion is thought to be the major route of drug elimination, but precise dosing
guidelines in patients with abnormal renal function have not been determined. This phase I
and pharmacologic study of single agent Oxaliplatin is being conducted in adult cancer
patients with impaired renal function. Patients will be stratified into four groups based
upon their degree of renal impairment as assessed by a 24 hour creatinine clearance. Group
A will consist of 12 patients with normal renal function who will serve as pharmacologic
controls. The remaining 3 groups will start at different doses of Oxaliplatin based upon
their degree of renal dysfunction and dose escalation in these groups will proceed in a
manner in accordance with standard phase I trials with 3 patients per dose level until dose
limiting toxicity is observed. Pharmacokinetic monitoring will be performed in all patients
on study. The goals of this trial are to define the toxicities and pharmacokinetics of
single agent Oxaliplatin in this patient population and to determine recommended doses of
Oxaliplatin in patient with different degrees of renal dysfunction.
Patients must have histologically confirmed malignancy which is metastatic or unresectable
and for which standard curative or palliative measures do not exist or are no longer
Patients with prior chemotherapy, radiation therapy, hormonal therapy and immunotherapy
are allowed with the exception that patients cannot have had prior treatment with
Patients greater than or equal to 18 years of age.
Patients must have an ECOG performance status less than or equal to 2 (Karnofsky greater
than or equal to 60 percent) and a life expectancy of at least 3 months.
Patients must have adequate organ and marrow function which includes:
Leukocytes must be greater than or equal to 3,000/microliter.
Absolute neutrophil count must be greater than or equal to 1,500/microliter.
Platelet count must be greater than or equal to 100,000/microliter.
Total bilirubin within normal institutional limits.
AST (SGOT)/ALT(SGPT) less than or equal to 1.5 times the upper limit of normal.
Patients with no evidence of clinically significant neuropathy.
Women of child-bearing potential and men must agree to use adequate contraception.
Patients must have the ability to understand and the willingness to sign a written
informed consent document.
Patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering the
study, or within 6 weeks of prior platinum therapy will be excluded.
Patients undergoing therapy with other investigational agents will be excluded.
Patients with known brain metastaseswill be excluded.
Patients with a history of an allergy to platinum compounds will be excluded.
Patients with uncontrolled intercurrent illness including but not limited to ongoing or
active infection, symptomatic congestive heart failure, or unstable angina pectoris, or
cardiac arrhythmia will be excluded.
Women must not be pregnant or nursing.
Patients must not be HIV-positive or receiving anti-retroviral therapy (HAART).
Patients actively receiving renal dialysis treatments while on the study will be excluded.