This study is designed to provide bone marrow and/or blood cells for other research studies.
Patients participating in this study will be asked to provide small amounts of medical
information and undergo a limited physical examination designed to detect the presence of
any obvious blood disease. A blood and bone marrow sample will be obtained to verify that
the patient has normal blood cell production.
Researchers plan to obtain bone marrow samples to be used in laboratory studies directed
toward understanding the formation of blood cells. Bone marrow samples will be taken from
the hip bone of patients and healthy volunteers.
These samples are valuable to many research studies within the Hematology Branch of the
National Heart, Lung, and Blood Institute, including studies of normal and abnormal
production of blood cells, the viral causes of blood diseases, and the role of the immune
system in bone marrow failure and related conditions.
This protocol defines in general terms the purposes for which blood and bone marrow
specimens will be collected by members of the Hematology Branch and the conditions under
which the sampling will be performed. Samples of blood and bone marrow from healthy
volunteers and from patients are indispensable for many research projects, including studies
of normal and abnormal hematopoiesis, the viral etiology of blood diseases, and the role of
the immune system in marrow failure and related conditions.
- INCLUSION CRITERIA:
Healthy volunteers age greater than or equal to 18 years.
Subjects with hematologic disease age greater than or equal to 2 (for subjects less than
18, blood and bone marrow specimens will be obtained concurrently with clinically
History of a significant bleeding disorder.
Abnormal host-defense mechanisms.
Neal S Young, M.D.
National Heart, Lung, and Blood Institute (NHLBI)