This study will attempt to develop and validate improved subjective measures of pain
sensation and use these measures to evaluate pain sensitivity in patients.
Normal healthy volunteers and dental patients undergoing third molar extraction may be
eligible for this study. Participants will undergo the following procedures:
Volunteers: Volunteers will participate in two 90-minute sessions in which they will receive
and rate four heat stimuli per minute applied to the skin for a maximum of 36 minutes. The
heat stimuli range from 37° (Degree)C to 51° (Degree)C (99° (Degree) F to 124° (Degree) F)
and last 2 to 3 seconds. A drug commonly used in dental treatments may be administered
during the second session. This will be either a maximum of 0.15 mg fentanyl, a
short-acting narcotic pain killer, or a maximum of 5 mg saline, an inactive substance
Dental patients: Dental patients will participate in two 60-minute sessions. The first
session will be on the day before the third molar extraction, and the second session will be
immediately before the dental procedure. The heat stimulus procedure will be identical to
that described above for normal healthy volunteers.
Mismanaged pain is still a major medical problem. Many pain syndromes have no effective
treatment, and many are managed poorly. Basic and applied research on pain treatment is
hampered by the unobservable nature of pain sensation and the lack of validated measures of
The purpose of this protocol is to develop and validate improved subjective measures of pain
sensation and use these measures to evaluate pain sensitivity in clinical populations.
Normal volunteers rate experimentally-evoked pain sensations before and after double-blind
administration of the opioid fentanyl or saline placebo. Patients rate
experimentally-evoked pain sensations without any drug administration.
Normal Volunteers, including NIH employees, will serve as subjects.
No subjects with any painful disease or diseases in which altered pain sensitivity is
No subjects will be included with poor general health, history of significant illness,
history of psychotic disorder or recent emotional distress, serious heart, lung, or liver
disease, or pregnancy.
Subjects also will be excluded on the basis of history of allergy to any of the
medications, history of chronic or recent drug use that may alter pain response, or
chronic drug abuse.