An important mission of the National Institutes of Health (NIH) is to develop and carry out
research studies designed to improve understanding of disease processes and treatments.
Clinical research continues to become more focused on specific diseases and the signs and
symptoms of diseases in specific groups of people and patients.
This study is designed to permit inpatient evaluation and care of patients with heart
disease who do not qualify to participate in research studies being conducted by the
Cardiology Branch of the National Heart, Lung, and Blood Institute (NHLBI). These patients
are valuable to the Cardiology Branch of the NHLBI because they help to improve training and
experience of its researchers.
An important mission of the NIH is to the conduct of research that elucidates biological
mechanisms, pathogenesis and treatment of diseases. Clinical research has evolved into an
increasingly narrow focus on specific diseases and disease presentations in select subgroups
of patients. It is desirable and consistent with Clinical Center policy, for clinical
investigators to maintain exposure to a more broad spectrum of disease and disease
presentations than mandated by the clinical research protocols in order to preserve clinical
skills of physician and nursing staff, ensure adequate training of clinical research
fellows, and stimulate ideas for future clinical research. This protocol permits evaluation
and treatment of patients with cardiovascular diseases who do not fulfill eligibility
criteria for participation in existing clinical research protocols, but who are of medical
interest for the purpose of training professional staff.
- INCLUSION CRITERIA:
Patients with cardiovascular disease may participate in this training protocol. The
following is a representative list of the types of patient presentations and potential
diagnoses eligible for this protocol:
Coronary artery disease with effort or rest angina or inducible myocardial ischemia as
determined by noninvasive testing.
Valvular heart disease.
Cardiomyopathies, including restrictive, congestive, and hypertrophic phenotypes.
Peripheral-artery disease of upper or lower extremities, with intermittent pain with
activity (e.g. claudication) or limb-threatening ischemia.
Renovascular disease with uncontrolled hypertension, intermittent pulmonary edema, or
evidence of ischemic nephropathy.
Congenital heart disease, with communications between chambers or major vessels
Heart surgery patients treated at the Clinical Center prior to closure of the Heart
Surgery Branch in 1990
Pregnancy, for those patients who require testing or treatment requiring dobutamine,
gadolinium or contrast media or radiation exposure.
Inability of patient, parent or legal guardian to provide informed consent.
Robert J Lederman, M.D.
National Heart, Lung, and Blood Institute (NHLBI)
Annette Stine, R.N.
Phone: (301) 402-5558