Individuals interested in becoming prospective bone marrow donors and joining the Registry
of the National Marrow Donor Program (NMDP) should do so by calling 301-496-0572, the phone
number of the NIH Marrow Donor Center. An appointment will be made to have a health history
taken and to have a buccal swab collected for tissue (HLA) typing. The current protocol only
involves donors already registered with the NMDP, who have been identified as "perfect
matches" for an unrelated patient requiring a bone marrow transplant, and who require
expedited medical evaluation prior to marrow collection.
The National Marrow Donor Program (NMDP) was established in 1987 in order to (1) create a
registry of volunteer, prospectively tissue-typed, unrelated bone marrow donors, (2)
facilitate the performance of matched unrelated donor marrow transplants through a
coordinated circuit of Donor Centers, Collection Centers and Transplant Centers throughout
the United States, and (3) evaluate the outcome of such transplants and identify future
areas of research in the field of unrelated donor marrow transplants. The NIH Marrow Donor
Center, a participant in the NMDP, is currently the second largest hospital-based Donor
Center in the nation, with approximately 55,900 active donors on its registry. 402 NIH
unrelated donors to date have undergone 429 marrow or blood stem cell harvest for an NMDP
recipient, and the current rate of such harvests is three per month. Once an HLA-matched
donor in the NIH Donor Center registry is identified through the NMDP computer network, the
donor must undergo a medical evaluation to determine suitability for marrow harvest. This
evaluation consists of a medical history, a physical examination, routine blood work, EKG,
chest x-ray, and urinalysis, and generally takes 4 to 6 weeks. A "third party" non-NIH
physician usually performs the evaluation, with the costs reimbursed by the NMDP.
Occasionally, an expedited evaluation of an unrelated donor must be performed, due to the
urgency of the need for a transplant in the recipient, and there is insufficient time to
accomplish this work-up using the routine "third-party" physician's office mechanism. This
protocol shall provide a means by which prospective NIH unrelated marrow donors
participating in the NMDP program can undergo an expedited medical evaluation to determine
suitability for marrow donation. It is expected that not more than 5 to 10 donors per year
shall require such expedited evaluation.
- INCLUSION CRITERIA:
Must meet same criteria as that of a volunteer blood donor.
History of hepatitis.
History of intravenous use of illicit drugs.
History of activities that increase the risk of exposure to HIV or hepatitis viruses.
Confirmed positive test for HIV
Inability to tolerate general anesthesia.
Diabetic patients will be excluded.
Pregnant patients will be excluded.