This study is divided into two parts. The first part of the study will use MRI technology
to view the brain structure of patients with neurological disorders and normal volunteers.
This portion of the study will attempt to detect specific areas of damage in the brains of
patients with amnesia and dementia. It will also try to correlate the amount of brain
damage with performance on tests used to measure memory.
In the second part of the study, researchers plan to use MRI technology to study brain
function of patients with neurological disorders and normal volunteers when they perform
tasks. MRI signals during task performance will be used to record areas of the brain
receiving more blood flow indicating increased activity.
Researchers believe this study will help improve existing methods of evaluating patients
with neurological disorders. In addition, this study may contribute information about areas
of the brain involved in thought processing and motor and sensory function.
We wish to use MRI technology to study brain structure (Part 1) and function (Part 2) in
several neurological disorders and in normal controls. In Part 1 of this protocol, we
describe our interest in using detailed MRI brain structure analysis to identify predicted
specific neural structure atrophy in patients with selective amnesia and dementia and to
attempt to associate the magnitude of atrophy in these neural structures with performance on
selected memory tests. In Part 2 of this protocol, we outline our interest in utilizing
newly developed MRI techniques to identify selective changes in local brain blood volume,
blood flow, and other physiological parameters during functional stimulation. Recent
developments permit recording of MRI signals that are indicative of regional cerebral blood
volume and blood flow changes. Local changes in these physiological measures appear to
topographically overlap with expected areas of functional brain activation. The advantage
of this method over Positron Emission Tomography is the exquisite spatial resolution of MRI.
This MRI technique is new and has had only limited use so far. The studies in Part 2 of
this protocol should help develop the method and begin to answer fundamental biological and
functional questions about the representation and activation of cognitive, motor, and
Subjects between the ages of 18 and 80.
Patient must be able to give informed consent.
Patients with ferromagnetic objects in their bodies which might be adversely affected by
MRI (surgical clips or metal fragments in or near brain, eye or blood vessels, cardiac or
neurological pacemaker, cochlear impairments) will be excluded.
Pregnant or lactating women will be excluded. A pregnancy test will be administered to
women of childbearing age.