Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of
the human body without the use of X-ray (radiation). MRI is especially useful when studying
the brain, because it can provide information about certain brain functions. In addition,
MRI is much better than standard X-rays at showing areas of the brain close to the skull and
detecting changes in the brain associated with neurological diseases. In this study
researchers will use MRI to gather information about the processes that control human
movement and sensory processing.
The purpose of the study is to investigate how the brain is activated when remembering,
thinking, or recognizing objects. Researchers would like to determine what happens to brain
functions when patients have trouble remembering, thinking, or recognizing objects following
the start of disorders in the brain and nervous system. In addition, this study will
investigate the processes of motor control in healthy volunteers and patients with disease.
The main purpose of the studies presented in this protocol is to investigate the physiology
of motor control in health as well as the pathophysiological modifications taking place
during disease. Patients and normal volunteers will be scanned at rest and during different
tasks, either while making repetitive movements or undergoing sensory stimulation. These
studies should provide new insight concerning the processes that control human movement and
sensory processing. The studies described in this protocol will be conducted by systems
operating on 1.5 Tesla up to 4 Tesla, including a system at 3 Tesla which is going to be
installed in near future.
Patients with movement disorder and normal volunteers.