Alzheimer's disease is a condition marked by the deterioration of mental function. The
disease usually begins in late middle life and results in death in 5 to 10 years. Patients
with Alzheimer's disease typically suffer from memory loss, confusion, and disorientation.
The condition has become a major medical and social problem in the United States because of
the increasing number of people living beyond the age of 65. The actual cause of
Alzheimer's disease is unknown.
Researchers believe that Alzheimer's disease, or at least a portion of cases, may be an
inherited condition. As a result, many new techniques have been developed to study the
genetic causes of Alzheimer's disease and other neurological disorders. Many of these
genetic techniques require blood samples and a family pedigree. A pedigree is a chart,
similar to a family tree, that shows a patient's family history.
The purpose of this study is to collect family and psychosocial information, blood, and
biopsy samples from patients with neurological diseases, their families, and normal
volunteers. This information gathered will be used to learn more about diseases that affect
This is a screening and follow-up Protocol. Recent technological advances have facilitated
the development of new approaches for investigating the underlying genetic basis of
neurological disorders, but genetic questions remain open and on going. Application of many
genetic techniques require a family pedigree and blood sample. Peripheral blood
lymphoblasts which are banked also serve as a renewable source for harvesting DNA which can
be used for developing genetic markers in the future. This study will allow collection of
family and psychosocial information and blood specimens from patients with neurological
diseases, their families, and normal control subjects.
Need to know extensive family history information.