Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in
the blood. This study is designed to improve understanding of normal, as well as abnormal,
lipoprotein metabolism and the role it plays in the development of hardening of the arteries
Patients participating in this study will receive an intravenous (directly into the vein)
injection of a small amount of specially prepared amino acids. The amino acids being
injected are the same amino acids present in a normal diet. The amount of amino acid given
will be less than the amount eaten in a protein-rich meal. The amino acids will be labeled
with nonradioactive heavy isotopes which are also present in the environment n low amounts.
Patients participating in the study will be required to have blood samples taken, and
provide urine samples throughout the course of the study. In addition, patient will be
required to follow a specially formulated diet. Patients will be weighed throughout the
course of the study.
Apolipoproteins regulate the metabolism of lipids and lipoproteins in plasma of humans. In
order to investigate the roles of apolipoproteins in these processes, we plan to quantitate
the kinetics of the metabolism of apolipoproteins utilizing nonradioactive isotope labeled
The subjects for these investigations will be either healthy normal volunteer control
subjects or patients who have a dyslipoproteinemia.
Subjects must be 18-80 years old.