Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are diagnostic
tests that allow researchers to look at different chemical properties of tissue. Magnetic
resonance imaging and spectroscopy studies can be used to gather or evaluate information
about various aspects of patient s bodies or to monitor changes in the biochemistry and
physiology of patient s bodies.
Unlike other diagnostic techniques (CT scan and PET scan) MRI and MRS do not use ionizing
radiation. Some studies have shown that MRI is more effective at distinguishing normal parts
of the anatomy from abnormal anatomy, especially in the brain. MRI has become the diagnostic
test of choice for evaluating patient with multiple sclerosis.
The purpose of this study is to evaluate normal volunteers and patients with a variety of
diseases with magnetic resonance imaging. Researchers will attempt different magnetic
resonance imaging methods and techniques as well as different levels of magnetic strength.
MRI is a constantly evolving imaging modality. Pulse sequences are often modified to improve
their performance. However, many of these changes have not yet been approved by the FDA and
therefore, are not considered standard of care. Some of these sequences require the use of
new types of imaging coils, which are also investigational.
The major purpose of this protocol is to inform patients undergoing MR scans in the Clinical
Center that they be scanned with MRI sequences and/or coils which may or may not be FDA
approved and to get the patient s consent for this. This is not a formal research study since
specific disease entities and specific pulse sequences are not studied in a systematic way.
Rather, the purpose is to give NIH patients access to gradual improvements in MR technology
that would otherwise not be available to them.
All patients who, by virtue of the NIH protocol in which they are enrolled, qualify for MRI
will be eligible for participation in this protocol.
Up to 99,999 participants will be enrolled in this study.
- INCLUSION CRITERIA:
All patients undergoing MRI in the Clinical Center.
Patients must be able to provide informed consents.
No contraindications to MRI.
Inability to understand consent form or consent process and the absence of a suitable
Patients in whom the scan must be performed quickly, i.e. those patients under anesthesia,
anxious patients, those requiring emergency medical care, or others in which it is deemed
inappropriate to prolong a study.
Refusal to Participate.