This study is designed to allow researchers to use transelectrical stimulation to explore
the function of the human nervous system and improve diagnosis of neurological disorders.
Transcranial electrical stimulation is a non-invasive technique that can be used to
stimulate brain activity and gather information about brain function. Electrical
stimulation involves placing electrodes on the scalp or skin and passing an electrical
current between them. When this is done, an electrical field is created that activates
areas of the brain that control muscles. Muscle activity as a result of the stimulation can
be recorded and analyzed.
This protocol application is written to permit us to use transcranial electrical
stimulation, a safe and noninvasive method for activating the brain, spinal cord, or
proximal nerves through the skin, in appropriate subjects. We will use this technique to
explore the function of the human central and peripheral nervous system and to aid in the
diagnosis of neurological disorders.
Males and females, ages 18 and over.
Diverse racial groups.
Amputees and others with whom we will have no patient-care relationship may also be
considered to be volunteers.
Patients will be recruited from those referred to the Human Motor Control Section, NINDS
who have neurological syndromes that are of interest.
On rare occasions we may attempt to study children as young as 10 years with TES.
Individuals without indwelling cardiac lines and pacemakers.
Patients recruited for study would come from those referred to the EMG laboratory and to
the Human Motor Control Clinic who would have distinct neurologic syndromes from well
defined peripheral and central nervous system lesions including hemiplegia from stroke,
trauma, tumor or focal demyelination (most commonly patients would have hemiplegia from
stroke), peripheral nerve lesions, amputations, spinal cord injury.
Normal volunteers, including NIH employees, would be healthy adults without history of
physical examination evidence of neurologic disease and individuals with different types
of amputations involving upper and lower extremities.
Volunteers may also be participants in the electrophysiological protocol (84-N-0196).
No history of epilepsy.