This study looks to identify genes that may affect a person's chances of developing bipolar
disorder (BP) and related conditions.
Bipolar affective disorder is a severe, heritable condition affecting about one percent of
the population. The mode of inheritance is poorly understood and probably involves multiple
loci of small to moderate effect. In this project, we use genetic mapping and sequencing
methods to identify genetic markers and variations that contribute to the risk of bipolar
disorder. Individuals diagnosed with bipolar disorder are studied, along with their
relatives. Phenotypic information obtained from clinical interviews and family history is
correlated with genotypic information obtained from genetic marker and sequencing methods.
The goal is to identify genes involved in bipolar disorder and related conditions so that
better methods of diagnosis, treatment, and prevention can be developed.
- INCLUSION CRITERIA:
Age > 18 yr
Able to provide informed consent
Diagnosed with bipolar disorder not attributable to substance abuse, neurological disease;
or a 1st or 2nd degree relative of an enrolled participant
Able to safely provide a blood or saliva sample
Active alcohol or substance abuse.
NIMH employees/staff and their immediate family members will be excluded from the study per