This study will compare cognitive behavioral therapy with a time-limited motivational
enhancement therapy to which naltrexone (Revia) or placebo medication is added. In this
randomized clinical trial, 160 alcohol-dependent outpatients, after 5 days of abstinence,
will receive one of the two psychosocial therapies and either naltrexone (Revia) or placebo
for a 12-week treatment period. Abstinence rates, alcohol use, and time to alcohol relapse
will be evaluated in all four groups along with measures of alcohol craving, biological
measures of alcohol consumption, drinking consequences, changes in self-confidence for
avoiding alcohol, and medication compliance. All study participants will be assessed for
measures of outcome variables at 3 and 6 months after completing the treatment protocol.
- Meets criteria for alcohol dependence, has not had more than one previous inpatient
- Consumes on average five standard drinks per day.
- Able to maintain sobriety for five days (with or without the aid of detoxification
medications) as determined by self-report, collateral report, and breathalyzer
- Able to read and understand questionnaires and informed consent.
- Lives within 50 miles of the study site.
- Currently meets criteria for any other psychoactive substance dependency disorder.
- Ever abused opiates.
- Used psychoactive substance abuse, except marijuana, within the last 30 days as
evidenced by patient report, collateral report, and urine drug screen.
- Meets criteria for disorders of major depression, panic disorder,
obsessive-compulsive disorder, post-traumatic stress syndrome, bipolar affective
disorder, schizophrenia, or any other psychotic disorder or organic mental disorder.
- Meets criteria for dissociate disorder or eating disorders.
- Has current suicidal or homicidal ideation.
- Need for maintenance or acute treatment with any psychoactive medication including
- Current use of disulfiram (Antabuse).
- Clinically significant medical problems that would impair participation or limit
- Hepatocellular disease.
- Sexually active females of child bearing potential who are pregnant, nursing, or who
are not using a reliable form of birth control.
- Have current charges pending for a violent crime.
- Does not have a stable living situation and a reliable source of collateral
- Has taken an opiate antagonist drug in the last month.