The long-range goal of this ongoing research program is to find more effective treatments
for alcohol dependence by combining medication with the appropriate psychosocial support.
This proposal has three specific aims: (1) to compare the effectiveness of naltrexone
(Revia) in three types of treatment settings; (2) to assess the effects of psychosocial
support on medication compliance and treatment retention; and (3) to investigate the
individual characteristics that may predict who is likely to benefit from additional
psychosocial support versus simple medication management.
- Meets criteria for current diagnosis of alcohol dependence.
- Subjects used more than 15 standard alcohol drinks (average)/week with at least 1 day
of 5 or more drinks in the past 30 days.
- Successful completion of medical detoxification.
- Lives within a commutable distance to the Treatment Research Center and agrees to
- Understands and signs the informed consent.
- Current diagnosis of any substance dependence other than alcohol, nicotine, or
- Evidence of opiate use in the past 30 days.
- Current treatment with psychotropic medications, including disulfiram (Antabuse)
(excluding short-term use of benzodiazepines for detoxification).
- History of unstable or serious medical illness, including need for opioid analgesics.
- Severe physical or medical illnesses such as AIDS, active hepatitis, significant
hepatocellular injury as evidenced by elevated bilirubin levels, and current severe
- Use of an investigation medication in the past 30 days.
- Female subjects who are pregnant, nursing, or not using reliable method of