Expired Study
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New Haven, Connecticut


Purpose:

This study will assess the ability of naltrexone (Revia) to reduce the risk of relapse in Alaska natives with alcohol dependence. The study will also examine whether a combination of naltrexone and sertraline (Zoloft) yields better abstinence rates than naltrexone used alone. Alaska Native individuals will be recruited into a 16 week outpatient study.


Criteria:

Inclusion Criteria: - Alaska Native having biological Alaska Native ancestry. - Meets criteria for alcohol dependence. - Prior to entering the study must be abstinent between 3 and 14 days and have a withdrawal assessment. - Stable residence to ensure that subjects can be located during the study. Exclusion Criteria: - Currently meets criteria for abuse or dependence on substances other than alcohol or nicotine. - Current use of disulfiram. - Psychotic or otherwise severely psychiatrically disabled. - Use of other psychotropic medications including antidepressants and anxiolytics. - Medical conditions that would not permit the use of sertraline or naltrexone, such as a history of unstable or severe hepatic, cardiovascular, metabolic, endocrine, gastrointestinal or kidney disease. - Hepatocellular disease or elevated bilirubin levels. - Females who are pregnant, nursing, or not using a reliable method of birth control. - Probation or parole requirements that might interfere with participation in the study. - Involvement in alcohol treatment other than provided by the study or AA. - Use of monoamine oxidase inhibitors in the past month. - Current use of Type 1C antiarrhythmics propafenone and flecainide.


NCT ID:

NCT00000451


Primary Contact:

Principal Investigator
Dr. Stephanie O'Malley
Yale University, New Haven, CT


Backup Contact:

N/A


Location Contact:

New Haven, Connecticut
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: July 27, 2017

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