The purpose of this study is to determine the long-term effectiveness of naltrexone
treatment in alcohol-dependent patients who respond to short-term treatment. Those who
respond to short-term treatment will be randomized to a 1-year, double-blind,
placebo-controlled maintenance phase with a 6-month posttreatment followup.
- Meets criteria for alcohol dependence.
- Expresses a desire to cut down or stop drinking.
- Currently meets criteria for dependence on substances other than alcohol.
- History of opiate dependence or evidence of current opiate use.
- Significant medical disorders that will increase potential risk or interfere with
- Liver function tests more than 3 times normal or elevated bilirubin.
- Female patients who are pregnant, nursing, or not using a reliable method of birth
- Inability to understand and provide a consent form.
- Treatment with an investigational drug during the previous month.
- Prior treatment with naltrexone.
- Chronic treatment with any narcotic-containing medications during the previous month.
- Sensitivity to naltrexone as evidenced by adverse drug experiences especially with
narcotic containing analgesics or opioid antagonists.
- Current treatment with disulfiram.
- More than 6 weeks of abstinence.
- Meets criteria for a major psychiatric disorder and is in need of, or currently