The study's purpose is to improve alcoholism treatment by investigating the combined
effectiveness of a psychotherapy (Coping Skills Training and Cue Exposure Treatment -
CSTCET) with naltrexone in a randomized clinical trial. Individuals will receive 2 weeks of
CSTCET or a control treatment as inpatients followed by 12 consecutive weeks of receiving
either naltrexone or placebo as outpatients. Followups at 24, 48, and 72 weeks after
treatment is completed.
- Meets criteria for alcohol dependence.
- Current diagnosis of dependence on other substances except nicotine.
- A history of psychosis or current psychotic symptoms.
- Current suicidality, homocidality, or psychiatric symptoms that require additional
- Current use of disulfiram (Antabuse).
- Evidence of significant cerebral, renal, thyroid, or cardiac disease.
- History of opioid abuse in the previous year.
- History of cirrhosis, hepatocellular disease, or elevated bilirubin.
- Females who are pregnant, nursing, or not using a reliable method of birth control.