This 12-week trial will compare individuals receiving naltrexone or placebo plus substance
abuse counseling therapy versus those receiving only substance abuse counseling therapy in a
rural, nonacademic setting. A followup period of 12 months is included. The effect on
service utilization and the cost of the addition of naltrexone to treatment services for
alcohol dependence also will be assessed. The study will expand existing research concerning
the effectiveness of naltrexone in clinical trials versus a clinical setting.
- Meets criteria for alcohol dependence (within the past 3 months).
- Meets criteria for another substance use disorder (except narcotic dependence) but
must identify alcohol as the primary substance of abuse.
- Must be able to provide an informed consent.
- Consent to random assignment and be willing to commit to possible medication
treatment and research follow-up.
- Must be eligible for treatment at the Dorchester Alcohol and Drug Commission.
- Meets criteria for opiate dependence.
- Clinically significant medical problems such as collagen-vascular disease,
cardiovascular, renal, gastrointestinal or endocrine problem that would impair
participation or limit medication ingestion.
- Hepatocellular disease.
- Women who are pregnant, nursing, or not practicing an effective means of birth
- Currently being prescribed naltrexone.
- Known sensitivity or allergy to naltrexone.