The purpose of this study is to: a) evaluate the effectiveness of ondansetron (Zofran) in
the treatment of alcohol dependent patients; b) investigate whether early versus late onset
alcoholism predicts treatment outcome; and c) determine whether the early and late onset
groups respond differently to treatment. Individuals will be "typed" into early onset and
late onset alcoholism groups. Individuals will be randomly assigned to a 12-week outpatient
- Meet criteria for alcohol dependence.
- Subjects with early onset alcoholism must also have a diagnosis of antisocial
- Understand the requirements of the study and be able to complete the questionnaires
and rating scales.
- Current diagnosis of substance dependence or self-report of having used narcotics
(opiates, cocaine, amphetamine-like substances, and hallucinogens) in the 30 day
period prior to study.
- Positive urine drug screen test for narcotics, barbiturates, or benzodiazepines.
- Receiving current psychotropic medications.
- Current history of other psychiatric disorders excluding nicotine dependence.
- Hepatocellular disease.
- Pregnant females.