Expired Study
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Baltimore, Maryland 21205


Purpose:

This study will evaluate the effectiveness of the medication naltrexone (Revia) for treating alcoholism. Individuals will be inpatients for a 2 week period and provide assessments of their alcohol withdrawal symptoms, craving, and mood. Following hospital discharge, individuals will be assigned randomly to receive naltrexone daily, naltrexone twice a day or a placebo. This part of the study will last 12 weeks, with regular measurements of drinking level, craving and mood. Assessments will be conducted 6 and 12 months after the beginning of the study.


Criteria:

Inclusion Criteria: - Meets criteria for alcohol dependence. - Committed to alcohol abstinence as a treatment goal. - Individuals will be required to identify two family members or close friends who are knowledgeable about their location, drinking behavior, and psychosocial status. Exclusion Criteria: - Meets criteria for any other psychoactive substance use disorder (excluding nicotine and caffeine). - Meets criteria for a major psychiatric disorder and are in need of or currently undergoing pharmacotherapy. - Females who are pregnant, lactating, or not using a reliable method of contraception. - Currently experiencing a serious medical condition that would place them at risk or interfere with study participation. - Experiencing acute hepatitis or liver failure or whose liver function test is more than 3 times normal. - Have a history of severe allergies, multiple adverse drug reactions or known allergy to naltrexone. - Vocabulary below the 5th grade reading level. - Abnormal MRI scan. - HIV infection due to the neurological sequelae. - Significant central nervous system diseases. - Seizure disorder or history of closed head trauma. - Neuroendocrine disorders. - Treatment with opiates within the last six months.


NCT ID:

NCT00000438


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

Baltimore, Maryland 21205
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 19, 2017

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