The purpose of this study is to identify the neurophysiologic indicators of cocaine or
methamphetamine use and withdrawal, to examine the relationship between subjects' reports of
depression, craving, and stimulant use, and neurophysiologic measures, and to identify
neurophysiologic measures which can be used to identify new treatments for stimulant
By Incorporating QEEG into clinical trails, the plan is to develop physiologic markers of
treatment efficacy, and to aid in the identification of effective treatments.
M/F ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the
study and sign informed consent.
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant
and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics.
Acute hepatitis. Other medical conditions that deem participation to be unsafe.