The purpose of this study is to evaluate clinical safety and pharmacological efficacy in the
treatment of cocaine dependence, to evaluate impact of treatment on craving, and to
correlate evidence of baseline neurotoxic damage of cocaine with treatment outcome and
M/F ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the
study and sign informed consent.
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant
and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics.
Acute hepatitis. Other medical conditions that deem participation to be unsafe.