The purpose of this study is to evaluate clinical safety issues pertaining to risperidone,
to cocaine and to its interaction, and to determine how pretreatment with risperidone
modifies the subjective as well as physiological effects of cocaine.
M/F ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the
study and sign informed consent.
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant
and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics.
Acute hepatitis. Other medical condtions that deem participation to be unsafe.