The purpose of this study is to evaluate clinical safety issues pertaining to lisuride, to
cocaine, and to its interaction in a chronic, crack dependent population, and to determine
how pretreatment with lisuride modifies the subjective as well as physiological effects of
M/F ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the
study and sign informed consent.
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant
and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics.
Acute hepatitis. Other medical condtions that deem participation to be unsafe.