The purpose of this study is to evaluate the efficacy and clinical safety of selegiline in
the treatment of cocaine dependence and to assess neurotoxicity (Magnetic Resonance Imaging,
MRI) post-hoc as a possible variable for future stratification in clinical trials.
M/F ages 21-50. Meets DSM-IV criteria for cocaine. Agreeable to conditions of study and
signed informed consent.
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant
and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics.
Acute hepatitis. Other medical conditions that deem participation to be unsafe.