The purpose of this study is to assess the abuse liability and examine the reinforcing
effects of intravenous buprenorphine and buprenorphine/naloxone combinations in healthy,
non-drug dependent volunteers.
not available at this time
Individuals must be healthy, non-drug dependent volunteers, be at least 18 years of age,
and have no prior history of drug or alcohol abuse or dependence. Subjects must have had
some minimal experience with opioids (e.g. at least two prior exposures)
Individuals with evidence of an active Diagnostic and Statistical Manual of Mental
Disorders (DSM-IV) Axis I psychiatric disorder (e.g. psychosis, manic-depressive illness,
organic psychiatric disorders), significant medical illness (e.g., liver or cardiovascular
disease) or pregnant female subjects are excluded from study participation.