The purpose of this study is to empirically test a series of medications to: 1) determine
each medication's efficacy in treatment of cocaine abuse/dependence; 2) find most effective
dose range for each medication. In this study, baclofen is tested.
16-week participation plus a 2 week lead in period. Participants are assigned randomly to
placebo or baclofen. Participant attend group meetings 3 x/week.
M/F ages 18-65. cocaine dependence according to Diagnostic and Statistical Manual of
Mental Disorders, 4th Edition (DSM-IV) criteria. Self-reported use within the last 30
days. Agreeable to conditions of study and signed informed consent.
Psychiatric disorder that requires medication therapy, history of seizures, pregnant
and/or nursing women, dependence on ethanol (ETOH) or benzodiazepines or other
sedative-hypnotics. Acute hepatitis. Other medical conditions that deem participation to