The purpose of this study is to empirically test a series of medications to: 1) determine
each medication's efficacy in treatment of cocaine abuse/dependence; 2) find most effective
dose range for each medication. In this study, amantadine is tested."
16-week participation plus a 2 weekk lead-in period. Participants are assigned randomly to
placebo or amantadine. Participants attend group meeting 3 times/week
M/F, ages 18-65. cocaine dependence according to DMS-IV criteria. Self-reported use within
the last 30 days. Agreeable to conditions of the study and signed informed consent.
Psychiatric disorder that requires medication therapy, history of seizures. Pregnant
and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative-hypnotics.
Acute hepatitis. Other medical conditions that deem participation to be unsafe.