The purpose of this study is to test the efficacy and safety of buprenorphine.
12 different sites for a total of 736 subjects (60 at Pizarro, 70 at West LA Tx center, 15
in the 1 year extension)
M/F, ages 21-50. opiate dependence according to DSM-IV criteria. Self-reported use within
the last 30 days. Agreeable to conditions of the study and signed informed consent.
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant
and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative-hynotics.
Acute hepatitis. Other medical conditions that deem participation to be unsafe.