The purpose of this study is to detect increasing medication dose results in heroin
cessation for patients still using, to determine if decreasing medication dose in patients
unable to tolerate medication dose increases retention, and to determine if blood levels of
methadone or buprenorphine correlate with clinical response.
M/F ages 21-50. Opiate dependence according to DSM-IV criteria. Self-reported use within
the last 30 days. Agreeable to conditions of study and signed informed consent.
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant
and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative-hynotics.
Acute hepatitis. Other medical conditions that deem participation to be unsafe.