View Clinical Trial (Medical Research Study)
Identification of Molecular Biomarkers to Stratify Patients With Refractory Asthma
| City: |
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Denver |
| State: |
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Colorado |
| Zip Code: |
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80121 |
| Conditions: |
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Asthma |
| Purpose: |
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The purpose of this study is to learn more about asthma in people who are not
well-controlled with current asthma medication (refractory asthma). The investigators will
compare data from refractory asthmatic patients here at National Jewish Health to mild
asthmatics subjects and to people without asthma. Study experiments involve looking at
samples from all 3 groups and comparing them at a molecular level. These laboratory
experiments may help identify subtypes of refractory asthmatics that require different
treatments.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- Able to receive Informed Consent
- At least 18 years of age
- ICS < 880 mcg (FP equivalents)
- PC20<=16 mg/mL
- No more than 1 oral steroid bursts in previous 12 months
- Less that 3 urgent care visit in previous 12 months
- No deterioration with <=25% decrease in steroids
- No near fatal asthma event
Exclusion Criteria:
- Pregnancy
- Current smoker, smoking within the past year or pack/year history >10 years
- Respiratory infection within past 6 weeks
- Antibiotics within the past 6 weeks
- Active lung disease other than asthma
- Cancer within past 5 years (excluding basal cell skin cancer)
- Active or chronic infection
- Hematological or autoimmune disease
- Unable to safely undergo bronchoscopy as determined by doctor or study doctor
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| NCT ID: |
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NCT01589198 |
| Primary Contact: |
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Principal Investigator
Richard Martin, MD
National Jewish Health
Jennifer Brandorff, BA
Phone: 303-398-1443
Email: brandorffj@njhealth.org
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| Backup Contact: |
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Email: pakj@njhealth.org
Juno Pak, BS
Phone: 303-398-1443
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| Location Contact: |
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Denver, Colorado 80121
United States
Jennifer Brandorff, BA
Phone: 303-398-1443
Email: brandorffj@njhealth.org
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 19, 2013 |
| Modifications to this listing: |
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