View Clinical Trial (Medical Research Study)
Repeated Challenge of Insufficient Sleep: Effects on Endothelial Function
| City: |
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Boston |
| State: |
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Massachusetts |
| Zip Code: |
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02215 |
| Conditions: |
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Repeated Short Sleep Schedule |
| Purpose: |
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The 24-hour-a-day, 7-day a week, work-world arrived within our lifetimes, and is here to
stay. Americans are working more and more, frequently at multiple jobs. The pattern of short
sleep during the week followed by attempts to recover on the weekend is in common practice,
but we know little of the associated health risks. What is the cost in terms of increasing
known risk markers for cardiovascular disease, of repeated nights of insufficient sleep, and
is this cost compounded with repetition, without adequate recovery? Evidence is accumulating
to suggest that short sleep duration is linked to the development of metabolic and
inflammation-associated diseases, such as cardiovascular disease. Mechanisms involved in the
development of cardiovascular disease include impaired vascular function and inflammation.
The current proposal is designed to investigate the effects of repeated periods of short
nocturnal sleep duration in 4 cycles (each cycle consisting of 3 nights of 4 hours of sleep
opportunity per night), and each cycle of short sleep followed by a single night of recovery
sleep. Vascular reactivity will be assessed using brachial artery flow mediated dilation,
and microcirculatory vasodilation will be assessed using perfusion imaging techniques. The
dependence of IL-6 and sVCAM-1 as measured in peripheral circulation, on vascular function,
will also be investigated.
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| Study Summary: |
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| Criteria: |
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Inclusion Criteria:
- Healthy volunteers
- Regular sleep-wake schedule
Exclusion Criteria:
- Diseases or medical conditions, including sleep disorders
- Current smoking
- Pregnant or nursing
- Recent time zone travel or shift work
- Regular medication use
- High blood pressure
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| NCT ID: |
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NCT01523535 |
| Primary Contact: |
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Principal Investigator
Janet M Mullington, Ph.D.
Beth Israel Deaconess Medical Center
Cait Estes
Phone: 617-667-5243
Email: cestes@bidmc.harvard.edu
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| Backup Contact: |
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N/A |
| Location Contact: |
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Boston, Massachusetts 02215
United States
Caitlin Estes, BSc
Phone: 617-667-5243
Email: CEstes@bidmc.harvard.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 22, 2013 |
| Modifications to this listing: |
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