View Clinical Trial (Medical Research Study)
Reliability of Central Venous Pressure Measurements From Peripherally Inserted Central Catheters vs. Centrally Inserted Central Catheters
| City: |
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Oklahoma |
| State: |
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Oklahoma |
| Zip Code: |
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73104 |
| Conditions: |
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Hemodynamics - Central Venous Pressure |
| Purpose: |
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The purpose of this study is to compare CVP measurements from CICCs and PICCs. The
investigators will also evaluate whether or not the duration of CICC placement affects the
differences in CVP measurements between the CICCs and PICCs. The investigators hypothesize
that the differences between the CVP measurements of the CICCs and PICCs will be clinically
insignificant.
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| Study Summary: |
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Centrally inserted central catheters (CICC) are commonly used in the intensive care unit
(ICU) for delivery of fluids, medications, and nutrition. They are also used to measure
central venous pressure (CVP) which provides critical information about blood volume status
and cardiac function of a patient. Currently, CICCs are the gold standard for measuring
CVP, but they have a number of associated risks including pneumothorax, major hemorrhage,
neck hematoma, and carotid puncture. An alternative to a CICC is a peripherally inserted
central catheter (PICC). A PICC can be placed with lower risks than a CICC, has a lower
rate of bloodstream infections, and provides longer-term IV access at a lower cost. PICCs
can be used to deliver fluids, medications, and nutrition. However, there is minimal
evidence that a PICC can measure CVP as effectively as a CICC. Therefore, a CICC is
preferred when a patient requires CVP monitoring in our ICU. Our aim is to compare CVP
measurements from CICCs and PICCs. We will also evaluate whether or not the duration of CICC
placement affects the differences in CVP measurements between the CICCs and PICCs. We
hypothesize that the differences between the CVP measurements of the CICCs and PICCs will be
clinically insignificant.
The goal of this study is to determine if the central venous pressure (CVP) measurements
obtained from a peripherally inserted central catheter (PICC) consistently correlate with
the CVP measurements obtained from a centrally inserted central catheter (CICC). If the
difference between the CVP measurements from the CICC and PICC are found to be clinically
insignificant, then it may be practical to place PICCs in favor of CICCs thereby avoiding
some of the potential complications associated with CICC placement. We also aim to evaluate
whether or not the duration of CICC placement affects the differences in CVP measurements
between the CICCs and PICCs. We hypothesize that the differences between the CVP
measurements of the CICCs and PICCs will be clinically insignificant.
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| Criteria: |
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Inclusion Criteria:
- Subject's ability to lay in a supine position with their hands at their sides during
CVP measurements
- A consent form signed by the patient or patient's representative
- Subjects that are age 18-90
- Subjects that have an indwelling CICC and are transitioning to a PICC for long-term
IV access
- CICC placed in the internal jugular vein or subclavian vein position
Exclusion Criteria:
- Inability to obtain consent
- Subjects under 18 years of age
- Non-English speaking subjects
- Subjects that are unable to lay flat due to pulmonary complications, increased
intracranial pressure (ICP), or unstable spinal cord injuries
- Subjects with known cardiac abnormalities (atrial septal defects or ventricular
septal defects, severe tricuspid valve disease, severe pulmonary hypertension,
Ejection fraction < 15%)
- Prisoners
- Subjects with known upper extremity deep vein thromboses (subclavian or distal)
- Subjects with non-functional CICC or PICC distal ports
- Subjects with femoral CICCs
- Pregnant women
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| NCT ID: |
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NCT01116973 |
| Primary Contact: |
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Principal Investigator
Pamela Roberts, MD
University of Oklahoma
Pamela Roberts, MD
Phone: 405-271-4351
Email: pamela-roberts@ouhsc.edu
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| Backup Contact: |
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Email: qaiser-khan@ouhsc.edu
Qaiser S Khan, MD,MPH
Phone: 405-271-8001 ext. 36016
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| Location Contact: |
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Oklahoma, Oklahoma 73104
United States
Pamela Roberts, MD
Phone: 405-271-4351
Email: Pamela-roberts@ouhsc.edu
Site Status: Recruiting |
| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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May 22, 2013 |
| Modifications to this listing: |
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