Characterization of Brachial Arterial t-PA Release, Vasodilator Function, and Vascular Compliance and Correlation With Fibrinolytic Balance, Oxidative Stress, and Inflammation Measures (SCCOR Project 1 Aim 3B)
| City: |
|
Nashville |
| State: |
|
Tennessee |
| Zip Code: |
|
37232 |
| Conditions: |
|
Obesity |
| Purpose: |
|
T-PA release is impaired in obese subjects. In order to have a better mechanistic
understanding of t-PA release, we will compare t-PA release to Flow Mediated Vasodilation,
Radial Artery Tonometry, and other markers of endothelial function and oxidative stress.
|
| Study Summary: |
|
|
| Criteria: |
|
Inclusion criteria:
1. Adults 18 years and greater
2. Healthy
Exclusion criteria:
1. PVC < 30
2. Hypertensive subjects on ACE inhibitors
3. Pregnant or nursing mothers
4. Diabetic with HbA1C > 7.5 or stigmata of end organ damage (neuropathy, retinopathy,
nephropathy, cardiomyopathy)
5. Cholesterol > 30 mg/dL above NCEP accepted level based on cardiac risk.
6. Triglycerides > 200
7. Previously diagnosed obstructive coronary artery disease, myocardial infarction or
left ventricular dysfunction (with or without a history of congestive heart failure)
8. Renal insufficiency (Creatinine ≥ 1.5 mg/dl)
9. History of cerebrovascular disease
10. Any chronic inflammatory disease (rheumatologic, inflammatory bowel disease, etc)
11. Uncontrolled Stage 2 Hypertension (160/100 mmHg), or end organ damage due to
hypertension (left ventricular hypertrophy, atrial fibrillation, hematuria, renal
insufficiency, prior cerebrovascular disease).
12. Angiotensin converting enzyme inhibitor use
13. Coagulopathy (INR ≥ 1.5, PTT ≥ 1.5 x control)
14. Other chronic medical illnesses at the discretion of the investigators
|
| NCT ID: |
|
NCT00780481 |
| Primary Contact: |
|
Principal Investigator
James AS Muldowney, MD
Vanderbilt University
James AS Muldowney, III, MD
Phone: 615-936-1720
Email: james.muldowney@vanderbilt.edu
|
| Backup Contact: |
|
Email: tami.neal@vanderbilt.edu
Tami Neal, RN
Phone: 615-936-1720
|
| Location Contact: |
|
Nashville, Tennessee 37232
United States
James AS Muldowney, III, MD
Phone: 615-936-1750
Email: james.muldowney@vanderbilt.edu
Site Status: Recruiting |
| Data Source: |
|
ClinicalTrials.gov |
| Date Processed: |
|
May 23, 2013 |
| Modifications to this listing: |
|
Only selected fields are shown, please use the link
below to view all information about this clinical trial. |
|
Click to view Full Listing
|